Retatrutide: Natty or Not? | Still Natty Abstract gradient background for Still Natty peptides guide
Still Natty
Back to Peptides

Retatrutide

Natty
fat lossweight losstriple agonistmetabolic healthdiabetessubcutaneous

What It Does

Reduces appetite and boosts metabolism for 24% weight loss. Improves blood sugar, lowers cholesterol, normalizes liver fat in 90% of users.

Natty Status Classification

This peptide is generally considered within the natty realm by some in the fitness community, particularly when used for therapeutic healing purposes. However, opinions vary, and competitive natural bodybuilding organizations may have different stances. Always check your federation's specific rules if you compete.

Description

Triple receptor agonist (GLP-1/GIP/glucagon) with superior weight loss (24% in trials) vs tirzepatide/semaglutide. Phase 3 trials. Not FDA-approved.

Full Description

Retatrutide (LY-3437943) is an investigational triple receptor agonist developed by Eli Lilly that simultaneously activates GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors.

This unique triple-agonist mechanism promotes superior weight loss compared to single or dual agonists by combining appetite suppression, enhanced insulin secretion, improved glucose homeostasis, and increased energy expenditure.

Phase 2 trials demonstrated exceptional efficacy with 24.2% mean weight reduction at 48 weeks (12mg dose), significantly outperforming tirzepatide (~21%) and semaglutide (~15%).

Beyond weight loss, retatrutide shows promise for treating type 2 diabetes, metabolic-associated steatohepatitis (MASH/NAFLD), with 90% of patients achieving liver fat normalization at highest doses.

Currently advancing through Phase 3 TRIUMPH clinical trials (5,800+ participants) for obesity, obstructive sleep apnea, and knee osteoarthritis.

Not FDA-approved; investigational use only.

Common side effects include dose-dependent gastrointestinal issues (nausea, vomiting, diarrhea) that typically diminish over time, plus modest heart rate increases (5-10 bpm).

Gradual dose titration over 12-16 weeks minimizes adverse events, with 16% discontinuation rate at highest dose versus 6% at lowest dose.

What is Lyophilized Powder?

Lyophilized powder is a sterile, freeze-dried medication that must be reconstituted (mixed with a liquid solvent, like sterile water) before it can be injected. This process extends the drug's shelf life and stability, making it ideal for temperature-sensitive products. The lyophilization process removes water from the peptide in a frozen state through sublimation, which preserves the physical and chemical properties until it is needed.

Application Methods

  • Subcutaneous injection

Product Names

  • Retatrutide

Benefits

  • Exceptional weight loss (24% at 48 weeks, highest among GLP-1 class)
  • Powerful appetite suppression and reduced food intake
  • Enhanced metabolic rate and energy expenditure via glucagon activation
  • Improved glucose homeostasis and HbA1c reduction (-1.2% vs placebo)
  • Liver fat normalization (90% of patients at high doses)
  • Improved insulin sensitivity and secretion
  • Reduced LDL cholesterol (~20%), triglycerides, and VLDL
  • Lower systolic blood pressure
  • Potential MASH/NAFLD reversal
  • Treatment for obesity-related conditions (OSA, knee OA)

Dosage Levels

  • Phase 2 protocol - Week 1-4: 2mg once weekly (subcutaneous)
  • Phase 2 protocol - Week 5-8: 4mg once weekly
  • Phase 2 protocol - Week 9-12: 8mg once weekly
  • Phase 2 protocol - Week 13+: 12mg once weekly (maximum dose)
  • Alternative titration: 1mg, then 2mg, then 4mg, then 6mg, then 8mg (escalate every 4 weeks)
  • Maintenance range: 4-12mg weekly depending on response and tolerability
  • Lower starting dose (2mg vs 4mg) reduces GI side effects

Research

Where to Buy

*Peptides are stored in form and need to be reconstituted with sterile bacteriostatic water before use.

Related Peptides

Ozempic

Natty

Reduces appetite and slows digestion for 15-21% weight loss. Improves blood sugar control. Lowers heart attack and stroke risk by 20%.

Tirzepatide

Natty

Reduces appetite for 21% weight loss. Significantly improves blood sugar and diabetes. Reduces sleep apnea breathing disruptions by 50%.

NAD+

Natty

Boosts cellular energy production and DNA repair. Activates longevity enzymes. Improves metabolism and mitochondrial health. Cellular benefits proven, human longevity unproven.
Last Updated: 10/19/2025